Radiofrequency perforator ablation is performed on perforator veins, which are short connections between the deep veins and the superficial veins. Perforator veins can suffer the same sort of valve damage and retrograde blood flow(venous reflux) as other veins. The majority of patients with vein disease who experience skin changes, which may eventually result in leg ulcers if left untreated, are found to have reflux in perforator veins near their ulcers as well as in the superficial or deep veins.

Before recommending radiofrequency perforator ablation, the doctor will require a thorough medical examination, including a diagnostic ultrasound evaluation. This will help determine whether or not the procedure is appropriate for the patient.

Radiofrequency perforator ablation is an outpatient procedure which is performed in the doctor's office under local anesthesia only. Patients generally experience little or no pain or "down time," and often feel relief from their symptoms right away.